Insulines & Buguanides
Insulin in bodybuilding
Insulin is very popular among weightlifters, because it is one of the most powerful anabolics.
It several times strengthens the synthesis of proteins, carbohydrates and fats, promotes faster penetration of glucose, amino acids and fatty acids into cells. Other tasks of insulin include:
- Deceleration of the breakdown of carbohydrates and proteins.
- Increase in the level of branched polysaccharide in the liver and muscles.
- Reducing sugar in the blood, by increasing the digestibility of glucose tissues.
- Improved energy metabolism.
- Reducing the oxidation of substrates and improving their recovery.
With the introduction of a large amount of insulin into the body, the sugar content in the blood drops sharply. As a result, the defensive reaction of the body is activated – the growth hormone begins to be thrown into the blood, as a result of which the blood sugar level again rises.
Sometimes the level of growth hormone rises by five, or even more times. As a result, anabolism increases dramatically. And insulin contributes not only to the release of the hormone, but also to the strengthening of its work.
Effects of insulin
Insulin has a mass of effects, the main categories are:
- Anabolic effect
- Anticatabolic effect
- Metabolic effect
- Anabolic effect of insulin
Insulin enhances the absorption of muscle cells by amino acids, especially leucine and valine. It also enhances DNA replication and protein biosynthesis, transport to a magnesium cell, phosphate as well as potassium ions, also enhances the synthesis of fatty acids and their subsequent esterification into adipose tissue and into the liver insulin promotes the transformation of glucose into triglycerides, and in the absence of insulin, all the way around – Mobilization of fats takes place.
Anticatabolic effect of insulin
Insulin suppresses the hydrolysis of proteins, i.e. reduces protein degradation, and also reduces lipolysis, i.e. reduces the flow of fatty acids into the blood.
Metabolic effects of insulin
Insulin activates the key enzymes of glycolysis, enhances the absorption of glucose by muscle cells, the intensity of synthesis of glycogen and other substances, and also reduces the intensity of gluconeogenesis (ie, reduces the formation of glucose in the liver).
I think it’s not necessary to write about all this in detail, because The likelihood that people are interested in this and that they will understand this is zero. Therefore, I propose to move on to a more interesting part of our discussion today.
Incorrect dosage determination can lead to serious consequences. Side effects of insulin are manifested by the introduction of a large number of insulin.
Excess of this hormone causes hypoglycemia – a critical reduction in sugar levels. If there was dizziness, a cold sweat struck, confusion, light sensitivity or weakness appeared, immediately take sweet food. Drowsiness after injection can also be a sign of hypoglycemia. If the symptoms do not disappear, it is advisable to call an ambulance, since hypoglycemia with a fatal outcome is possible. Long courses without interruption can provoke diabetes.
The pancreas gradually reduces the level of secretion of natural insulin if you inject the hormone by injection. At the level of scientific research, it was revealed that the tissues of this organ also change, because the process can be irreversible. However, no more or less valid recommendation regarding the duration of the course for athletes is not given. Because the process is always risky enough.
What effect does insulin have?
First. Reduces the amount of glucose, which is in the blood due to improved absorption in all cells of the body. Due to this effect, the synthesis of glycogen (in the liver and muscles) is improved and accelerated, but simultaneously the process of accumulation of adipose tissue is accelerated. Moreover, for insulin there is no difference which tissues become more permeable for glucose (fat or muscle). Also, insulin helps to reduce the amount of fatty acids in the blood, which is also the reason for the accumulation of fat.
The second. Insulin has an effect on the synthesis of proteins (enhances), and also provides the synthesis of amino acids. Due to this property, a large number of athletes often take insulin.
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