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Drug Aldactone is a potassium-sparing diuretic. In medical practice it is used to get rid of arterial hypertension and other pathologies. Before using the medication it is important to carefully read the instructions for use and consult a doctor who will determine the permissibility of using the medication.

Mechanism of action

The drug Aldactone has a diuretic, potassium-sparing and hypotensive properties.

Aldactone inhibits the absorption of sodium ions and increases the excretion together with urine of sodium, chlorine and liquid. The drug lowers the acidity of urine. The diuretic effect is observed 3 days after the beginning of the use and lasts for 3 days after stopping the medication. Reduction of pressure is due to accelerated elimination of sodium and a decrease in the volume of circulating blood. There is a hypertensive property 14 days after the start of the therapy.

Indications for use

According to the instructions for use, Aldactone is prescribed for the therapy of the following conditions:

  • nephrotic syndrome;
  • edema caused by heart disease;
  • Puffiness caused by cirrhosis of the liver;
  • edema, which were formed due to the period of pregnancy;
  • persistent increase in blood pressure;
  • preventive measures to develop an increased concentration of potassium in the blood.

Composition and form of release Aldactone

The drug is released in tablet form.

Produced “Aldactone” in the form of round tablets. Each tablet contains an active component of spironolactone in the amount of 25, 50 or 100 milligrams. Additional components are corn starch, magnesium stearate and lactose. The medication is packaged into cardboard boxes, each of which contains 2 blisters for 10 or 20 tablets.

Indication Information about Modiwake

The causative agent is ModafinilMODIWAKE Tablet is a medication that reduces sleepiness and increased alertness in patients with excessive sleep due to sleep disorders (narcolepsy). MODIWAKE is used in the treatment of sleep disorders characterized by hypersomnia, sleep disorders due to, temporary respiratory failure, obstructive sleep apnea / hypopnea syndrome, narcolepsy and excessive sleeptime to increase alertness in patients with a tendency to fall asleep (sleep episodes) in unstable conditions and times. It improves narcolepsy and prevents sleep attacks that may occur during the day.

What You Need To Know Modiwake

If you are allergic to the drug substance, you are not recommended to use this drug. MODIWAKE is used as a wake-up provider in patients who are prone to excessive sleep due to sleep disorders (narcolepsy). Treatment should
begin with the proposal or control of an experienced and experienced doctor on sleep disorders. It may cause addiction. Long-term use should be avoided.

If your heart beats have irregularities (arrhythmia) or high blood pressure (moderate or severe levels) that can not be controlled; do not use this medicine.

Some cases the with In use of the MODIWAKE the Tablet the requires special Attention. So if you have any heart disease or history of a heart attack, you have an illness of alcohol or drug addiction in the past or depression, pessimistic emotional state, anxiety (anxiety / anxiety state) inform your physician about bipolar disorder (bipolar disorder) and bipolar disorder (mood changes, mood disorders) You can not use this medicine for you or you.

In the course of your treatment, if you feel depression, feel hostility or aggression towards other people, or feel a change in suicidal thoughts or behavior, talk to your doctor right away. If skin rash appears during your treatment, stop using the medicine and contact your doctor immediately.

Use this medicine for a maximum of 1 to 2 weeks or less. It can be addictive. If you need to use it for a longer period of time, your family and friends should be careful about changes in your mood.

Dosage adjustment should be made in geriatric patients. Avoid alcohol during your treatment. The effectiveness and safety of use of children in childhood has not yet been proven; children are under 18 years of age due to psychiatric side effects and serious hypersensitivity risks.

There is a low amount of lactose in the contents of the product. If you have been told by your doctor that you are unstable against some sugars, tell your doctor before taking this medicine.

Dizziness and blurred vision. Therefore, be careful in the activities that are vigorous and vigilant, such as using a car or a machine.

Do not use without consulting your doctor during pregnancy and lactation. It is not known whether it will harm the unborn baby. During breastfeeding, the mother goes to bed and may harm the breastfed baby.

Muscoril

Muscoril is indicated as an additional remedy for the treatment of muscle contractures in rheumatology.

Pharmacodynamics

Reklaks as an active substance contains thiocolchicoside, a semi-synthetic muscle relaxant, obtained from the natural glycoside colchicoside. Thiocolchicoside shows selective affinity for gamma-aminobutyric acid (GABA) and glycine receptors, which causes the drug to work at various levels of the nervous system, both with spasms of a local nature and with spasms of central origin.

Reblax does not have curare-like action, does not cause paralysis and does not affect the cardiovascular and respiratory systems.

Pharmacokinetics

Distribution

After oral administration, thiocolchicoside is first metabolized to the aglycone 3-demethylthiocolchicine-inactive metabolite. This process occurs through intestinal metabolism, which explains the absence of circulating thiocolchicoside in unchanged form in the blood plasma. The inactive metabolite is then glucurically conjugated to a pharmacologically active metabolite.

The maximum concentrations in the blood plasma of active and inactive metabolites are reached 1 hour after taking the drug. After receiving a single oral dose of 8 mg thiocolchicoside, the maximum concentration and AUC for the active metabolite are approximately 60 ng / ml and 130 ng · h / ml, respectively. For the inactive metabolite, these values ​​are significantly lower: the maximum concentration is approximately 13 ng / ml, the AUC varies from 15.5 ng / hr (up to 3 hours) to 39.7 ng hr / ml (up to 24 hours).

Excretion

The half-life of the active metabolite is 3.2-7 hours, for the inactive metabolite it is 0.8 hours.

After oral administration, 20% of the dose is excreted by the kidneys, 75-81% is excreted with feces.

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